Thermo-Mechanical Analysis of Brain Tissue During Freezing

TAO Ze; SU Lijun; LIU Shaobao

doi:10.21656/1000-0887.450118

Volume 45 Issue 6

Jun. 2024

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TAO Ze, SU Lijun, LIU Shaobao. Thermo-Mechanical Analysis of Brain Tissue During Freezing[J]. Applied Mathematics and Mechanics, 2024, 45(6): 710-718. doi: 10.21656/1000-0887.450118

Citation:

TAO Ze, SU Lijun, LIU Shaobao. Thermo-Mechanical Analysis of Brain Tissue During Freezing[J]. Applied Mathematics and Mechanics, 2024, 45(6): 710-718. doi: 10.21656/1000-0887.450118

Citation:

TAO Ze, SU Lijun, LIU Shaobao. Thermo-Mechanical Analysis of Brain Tissue During Freezing[J]. Applied Mathematics and Mechanics, 2024, 45(6): 710-718. doi: 10.21656/1000-0887.450118

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Thermo-Mechanical Analysis of Brain Tissue During Freezing

doi: 10.21656/1000-0887.450118

TAO Ze^{1, 2
,},
SU Lijun^{1, 2
,
,},
LIU Shaobao^{1, 2
,
,}

1.
State Key Laboratory of Mechanics and Control for Aerospace Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P.R.China
2.
MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P.R.China

Received Date: 2024-04-25
Rev Recd Date: 2024-05-15
Publish Date: 2024-06-01

Abstract

Abstract

Although the brain is the most important organ in the human body, its thermo-mechanical coupling mechanism during cryogenic freezing remains unclear. A thermo-mechanical model for the cryogenic freezing of brain tissue was established, considering the special shape of the skull and brain, the cerebrospinal fluid, the cranial constraints, and the frost-heave effects. Analyses of the temperature field, the phase field, and the pressure field caused by the frost heave of the cerebrospinal fluid during freezing show that, the temperature of the cerebrospinal fluid remains unchanged during coagulation, while the maximum temperature difference within the brain tissue could reach 20 K. The solid-liquid phase interface is about 0.3 mm thick, and the driving velocity is about 0.09 mm/s. The maximum displacement of the brain tissue due to freezing is about 0.12 mm near the skull, and the pressure gradient at the solid-liquid interface is as high as 500 MPa/mm, while the pressure inside the solid and the CSF keeps almost unchanged. This study provides a theoretical support for the human brain cryopreservation strategy and the brain protection.
- brain tissue,
- cerebrospinal fluid,
- poro-elasticity,
- frost heaving pressure

(Contributed by LIU Shaobao, M.AMM Editorial Board)

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References(32)

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