Neurodynamic Analysis of Mutual Antagonism Between Default Mode Networks and Task-Positive Networks

CHENG Xianjun; WANG Yihong; WANG Rubin

doi:10.21656/1000-0887.390027

Volume 40 Issue 2

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CHENG Xianjun, WANG Yihong, WANG Rubin. Neurodynamic Analysis of Mutual Antagonism Between Default Mode Networks and Task-Positive Networks[J]. Applied Mathematics and Mechanics, 2019, 40(2): 127-138. doi: 10.21656/1000-0887.390027

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Neurodynamic Analysis of Mutual Antagonism Between Default Mode Networks and Task-Positive Networks

doi: 10.21656/1000-0887.390027

Institute for Cognitive Neurodynamics, East China University of Science and Technology, Shanghai 200237, P.R.China

Funds: The National Natural Science Foundation of China（11232005;11472104）

Received Date: 2018-01-22
Rev Recd Date: 2018-04-13
Publish Date: 2019-02-01

Abstract

Abstract

The working mechanism of task-positive activation and task-negative activation is the fundamental element of cognitive function. The imbalance or impairment of this antagonism may induce a series of severe degenerative neurological diseases. However, the neural mechanism of this antagonism is unclear. Based on the mutual synaptic inhibitory assumption for the default mode network and the task-positive network, the numerical simulation of a working memory model was performed under multiple stimuli conditions. The results show that: 1) neural activities of task-positive and task-negative networks appear to antagonize each other; 2) the neural activity decay of the task-negative network will intensify as the count of stimulus directions of working memory increases; 3) the activity of the task-negative network will drop when the neural activity of the brain area related to working memory increases; 4) as the difficulty of working memory rises, the neural activity of the task-negative network will quickly decrease. These computational results match well with the experimental data. Since task-negative activation is the primary property of the default mode network, the mutual synaptic inhibition of default mode and task-positive networks makes the fundamental reason why the antagonism is generated between these 2 networks.
- task activation,
- task deactivation,
- default mode network,
- working memory,
- antagonistic relationship

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References(32)

References

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