Mass Transport in Solid Tumors(Ⅱ)——Drug Delivery

Lei Xiaoxiao; Wu Wangyi; Wen Gongbi; Chen Jianguo

Article Contents

Article Navigation > Applied Mathematics and Mechanics > 1998 > 19(12): 1063-1070

Lei Xiaoxiao, Wu Wangyi, Wen Gongbi, Chen Jianguo. Mass Transport in Solid Tumors(Ⅱ)——Drug Delivery[J]. Applied Mathematics and Mechanics, 1998, 19(12): 1063-1070.

Citation:

Lei Xiaoxiao, Wu Wangyi, Wen Gongbi, Chen Jianguo. Mass Transport in Solid Tumors(Ⅱ)——Drug Delivery[J]. Applied Mathematics and Mechanics, 1998, 19(12): 1063-1070.

Citation:

Lei Xiaoxiao, Wu Wangyi, Wen Gongbi, Chen Jianguo. Mass Transport in Solid Tumors(Ⅱ)——Drug Delivery[J]. Applied Mathematics and Mechanics, 1998, 19(12): 1063-1070.

PDF( 1655 KB)

Mass Transport in Solid Tumors(Ⅱ)——Drug Delivery

Department of Mechanics and Engineering Science, Peking University, Beijing 100871, P. R. China

Received Date: 1997-05-05
Publish Date: 1998-12-15

Abstract

Abstract

Based on the flow field solution of the three-porous-medium model for tumor microcirculation,the diffusion-convection equations are solved with varions initial and boundary conditions using finite element method.The concentration profile of two therapeutic agents immunoglobulin G(lgG) and its antigen-binding fragment(Fab) in blood,lymph and intersitial flaid are obtained for normal-tissue-surrounded tumor.The effect of tumor microvasculature,lymph function,drug injection mode,the molecular weight and binding kinetics of the drug on the distribution in tumors are considered.
- three-porous-medium model,
- solid tumor,
- drug delivery,
- diffusion-convection equations,

FullText(HTML)

References(4)

References

[1]	O.Kedem and A,Katchalsky,Thermodynamic analysis of the permeability of biological membranes to non-electrolytes,Biochemical ET Biophysica Acta.,27(1958),229-254.
[2]	L.T.Baxter and R.K.Jaai.Transport of fluid and macromolecules in tumors I,Role of interstitial pressure and convection.Microvascular Res.,37.1(1989),77-104.
[3]	L.T.Baxter and R.K.Jain,Transport of fluid and macromolecules in tumors Ⅱ,Role of heterogeneous perfusion and lymphatics,Microvascular Res.,40,2(1990),246-263.
[4]	L.T.Baxter and R.K.Jain,Transport of fluid and macromolecules in tumors Ⅲ,Role of binding and metabolism,Microvascular Res.,41,1(1991),5-23.