生物热-力-电生理耦合学

孙学超; 刘少宝; 林敏; 徐峰; 卢天健

doi:10.21656/1000-0887.450079

生物热-力-电生理耦合学

doi: 10.21656/1000-0887.450079

孙学超^1,,
刘少宝¹,
林敏²,
徐峰²,
卢天健^1, ,

1.
南京航空航天大学航空航天结构力学及控制全国重点实验室，南京 210001
2.
西安交通大学生物医学信息工程教育部重点实验室仿生工程与生物力学研究所(BEBC)，西安 710049

(我刊编委刘少宝、林敏、卢天健来稿)

基金项目:

国家自然科学基金(重点项目) 12032010

江苏省研究生科研与实践创新计划项目 KYCX23_0351

详细信息

作者简介:
孙学超(1996—)，男，博士生(E-mail: xcsun@nuaa.edu.cn)

通讯作者:
卢天健(1964—)，男，教授，博士，博士生导师(通讯作者. E-mail: tjlu@nuaa.edu.cn)

中图分类号: O34
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出版历程
- 收稿日期: 2024-03-29
- 修回日期: 2024-04-16
- 刊出日期: 2024-06-01

The Bio-Thermo-Mechano-Electrophysiology

1.
State Key Laboratory of Mechanics and Control for Aerospace Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210001, P.R.China
2.
Bioinsopired Engineering and Biomechanics Center (BEBC), The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an 710049, P.R.China

(Contributed by LIU Shaobao, LIN Min, LU Tianjian, M.AMM Editorial Board)

摘要

摘要:
由于温度、机械力、生化等多种影响因子对机体的生物学行为产生重要影响，生物体在多物理场下保持动态平衡是其正常活动的关键条件.研究生物热-力-电生理耦合行为，旨在交叉融合多个学科，建立生物传热学、生物力学、神经生理学等数理模型，系统开展跨尺度热-力-电生理耦合行为研究，并将成果应用于生物医学领域，对理解生物体的正常功能以及重大疾病的病理机制和有效诊治具有重要意义.其核心思想在于发现关键科学问题、识别交叉学科，并集成学科优势，推动理论创新和技术创新，为生命医学领域带来新突破.该文以剑桥大学和DNA双螺旋结构的发现为背景，以大脑、皮肤、牙齿等为例，介绍生物热-力-电生理耦合学这一新兴交叉学科的起源和内涵.
- 皮肤 /
- 牙齿 /
- 大脑 /
- 跨尺度 /
- 学科交叉
Abstract:
The behaviors of biomaterials are influenced by a multitude of factors including temperature, mechanical load, and biochemical environments. The dynamic equilibrium of organism within a multiphysical field is crucial for its physiological functions. Therefore, a comprehensive investigation into the bio-thermo-mechano-electrophysiological behaviors is of great significance for the elucidation of pathologies and the development of effective diagnostic and therapeutic strategies. Such inquiries inherently require a multidisciplinary approach, necessitating the integration of diverse disciplinary knowledge and the pioneering of innovative cross-disciplinary research. The core idea is to discover key scientific questions, identify interdisciplinary disciplines, integrate disciplinary advantages, promote theoretical and technological innovations, and bring new breakthroughs in the biomedical field. With the discovery of DNA double helix structure in Cambridge University as the background, and the tissues of brain, skin, and teeth, etc. as examples, this paper introduces the evolution and intension of bio-thermo-mechano-electrophysiology, a new interdisciplinary subject.
- skin /
- teeth /
- brain /
- cross-scale /
- interdisciplinary
edited-by

edited-by
注释:

1) (我刊编委刘少宝、林敏、卢天健来稿)

HTML全文

图 1 1953年在《自然》杂志发表的《Molecular Structure of Nucleic Acids》一文揭示了DNA的双螺旋结构^[6]

Figure 1. The double helix structure of DNA revealed in the article "Molecular Structure of Nucleic Acids" published in Nature in 1953^[6]

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图 2 剑桥市Eagle老酒吧及其门外纪念DNA结构发现之地的浅蓝底色铭牌

Figure 2. The light blue plaque outside the Eagle Pub in Cambridge commemorating the place where the DNA structure was discovered

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图 3 皮肤烫伤起泡及皮肤层级结构示意图：皮肤的表皮最薄但最硬，其弹性模量(~100 MPa)是真皮的10倍，故很容易在热刺激下产生热不匹配现象，进而起泡

Figure 3. Schematic diagram of skin blistering and skin hierarchy: the epidermis of the skin is the thinnest but hardest, and its Young's modulus (~100 MPa) is 10 times that of the dermis, so it is easy to produce thermal mismatch under thermal stimulation, and then blistering

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图 4 生物组织的非均质、多组分结构^[10]

Figure 4. Heterogeneous, multicomponent structures of biological tissues^[10]

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图 5 皮肤热疼痛统一模型示意图^[44]

Figure 5. Schematic diagram of the unified model of skin heat pain^[44]

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图 6 皮肤热-力-电生理耦合行为^[44]

Figure 6. Skin thermo-mechano-electrophysiological coupling behavior^[44]

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图 7 生物打印技术典型应用

Figure 7. Typical applications of the bio-printing technology

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图 8 牙齿冷/热疼痛力学机理具有显著差异^[9]

Figure 8. The mechanical mechanisms of cold/heat pains with significant differences^[9]

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图 9 输尿管壁结构及流固耦合作用下结石-输尿管力学模型^[48]

Figure 9. The ureteral wall structure and the calculus-ureter mechanical model under fluid-solid coupling^[48]

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图 10 脑组织快速压缩-松弛实验

Figure 10. The rapid compression-relaxation test of brain tissue

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图 11 黏弹性水凝胶用于脑外伤治疗，加速脑外伤修复^[53]

Figure 11. Viscoelastic hydrogels used in the treatment of brain injury to accelerate the repair^[53]

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图 12 生物热-力-电生理耦合学发展进程

Figure 12. Development of biothermo-mechano-electrophysiological coupling

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图 13 理-工-医多学科交叉研究

Figure 13. Multidisciplinary study of science, engineering and medicine

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